Age-related testosterone declines can be detected in men’s fingernails.

Abstract Testosterone plays multiple roles in the regulation of development, physiology, reproduction, and behavior. Age-related testosterone declines are expected in the population. However, measuring circulating testosterone is especially challenging since concentrations are labile, responding to social situations and challenges. Matrices that integrate long-term testosterone levels are therefore valuable as biomarkers of mean, as well as chronic exposures. Here we report on a simple method to extract and measure accumulated testosterone from human fingernails using commercial EIA kits. Further, we demonstrate known human testosterone sex and age trends. Our method is especially useful for quantifying testosterone in men's nails, where a small amount of matrix is required. Thus, this approach is a potential tool for biomonitoring endogenous as well as exogenous testosterone exposure. We suggest considering nails as an alternative matrix for quantifying other steroids as well.

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Testosterone Matas D1, Koren L2

Author Information

1. Bar Ilan University, Ramat Gan, Israel ; [email protected].
2. Bar Ilan University , Faculty of Life Sciences , Ramat Gan, Israel , 5290002 ; [email protected]. Can J Physiol Pharmacol. 2017 Aug 1. doi: 10.1139/cjpp-2017-0193. [Epub ahead of print]

Link: https://www.ncbi.nlm.nih.gov/pubmed/28763621

by Gary Khodanian | Aug 1, 2017