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Immune Changes and Dysphoric Moods across the Postpartum

Abstract Problem
Little is known about postpartum immune recovery and relationships of common dysphoric moods, stress, immunology and endocrinology.
Method of Study
Healthy women (n=72) were followed for six postpartum months with immune and hormone measures and dysphoric moods and stress scales. A panel of cytokines produced in mitogen-stimulated whole blood assays were measured at each time, along with plasma levels of hsC-reactive protein (hsCRP), Interleukin-6 (IL-6), and a panel of hormones.
Results
Cellular immunity, measured by production of Interferon-gamma (IFNγ) and (Interleukin-2 (IL-2) from stimulated whole blood culture, was low in the early postpartum with changes by 3 months. Tumor necrosis factor alpha (TNFα) showed a similar pattern. Plasma levels of C-reactive protein and Interleukin-6 (IL-6) showed higher levels in the early postpartum. Mood disturbance scores dropped across the postpartum with a change in slope at 3 months. No significant relationships were found between immune, endocrine, and psychosocial measures.
Conclusions
Return to normal cellular immune function may take 3 to 4 months in the postpartum. Some aspects of early immunology (hsCRP and IL-6) probably reflect the latter stage of pregnancy, the stress of birth and the inflammation associated with involution. Dysphoric moods are higher in the early postpartum but are not related to immune factors or hormones.

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Progesterone Maureen E. Groer, PhD,1 Cecilia Jevitt, PhD,2 and Ming Ji, PhD1

Author Information

1. University of South Florida College of Nursing, 12910 Bruce B. Downs Blvd., Tampa, Fl 33647
2. Yale University School of Nursing, PO Box 27399, West Haven, CT 06515-7399
Am J Reprod Immunol. 2015 Mar; 73(3): 193–198. Published online 2014 Sep 17. doi:  10.1111/aji.12322 PMCID: PMC4323631 NIHMSID: NIHMS625005

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323631/

by Gary Khodanian | Sep 17, 2014

 
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