Oral contraceptive use and saliva diurnal pattern of metabolic steroid hormones in young healthy women.
The impact of oral contraceptives (OCs) on the saliva diurnal pattern of metabolic steroid hormones remained unknown.
Saliva samples were taken from young healthy women (11 OC users, 10 non-OC users) to analyze cortisol, dehydroepiandrosterone (DHEA) and testosterone 4 times (days 1, 8, 15 and 22) over one menstrual cycle.
OC use decreased saliva testosterone concentrations (p<.01) under all conditions of day and time, but not saliva cortisol. OC also decreased saliva DHEA concentrations during the first part of the day (p<.05), with a dampened amplitude in its diurnal pattern.
The clinical relevance requires further study.
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2 Département des Analyses, AFLD, France.
3 Laboratoire M2S, Université Rennes 2, France.
4 Laboratoire CIAMS, Université Paris Sud-Université Orléans, France; Département des Analyses, AFLD, France. Electronic address: [email protected]
by Oleg Vishnevski | Mar 3, 2015