Serum Progesterone and Estradiol Levels and the Mast Cells Count in Skin Tags among healthy Pregnant and Non-Pregnant Women: Correlation with Age of Pregnancy and Phases of the Menstrual Cycle
Skin tags (STs) are common benign skin tumors usually occurring on the neck and major flexors of elder people. STs are histologically composed of loose collagen fibers and dilated capillaries enclosed in a hyperplastic epidermis.
We aimed at investigating the possible correlation between each of serum level of progesterone and estradiol with mast cells count (MCC) in STs among healthy pregnant and non-pregnant females to check for their possible pathogenetic roles.
Participants and Methods:
Thirty participants with STs comprised two groups (15non-pregnant and 15 pregnant). One skin tag biopsy from each participant was histopathologically examined for mast cell count that was correlated with serum progesterone and serum estradiol measured using specific ELISA kits.
A statistically significant correlation between MCC and serum estradiol was detected in both of the study groups. There was no statistically significant correlation between MCC and serum progesterone in both of the studied groups. MCC in STs was statistically higher in the pregnant than the non-pregnant group.
There may be possible interaction of both mast cell and estradiol and both could be involved in the pathogenesis of STs.
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by Gary Khodanian | Jan 1, 2015